Manoj Kumar Jaiswal

October 12th, 2018

Manoj Kumar Jaiswal (Hindi: मनोज कुमार जायसवाल) (born Nov. 2, 1976) is an Indian neuroscientist. He is the full-time faculty (Instructor) in the Department of Psychiatry at the Icahn School of Medicine at Mount Sinai.

Jaiswal was born in 1976 in Varanasi (Hindustani pronunciation: [ʋaːˈraːɳəsi], also known as Benares, Banaras (Banāras [bəˈnaːrəs], or Kashi (Kāśī [ˈkaːʃi], a major religious hub in India and holiest of the seven sacred cities (Sapta Puri) in Hinduism and Jainism. He became interested in Biology at a young age and began doing research in the field as an undergraduate student.

In Jan 2008 he received his Ph.D. degree from the University of Goettingen in Germany. He was a Postdoctoral Fellow in 2009 at the Massachusetts Institute of Technology in Cambridge, Massachusetts. From 2010 to 2015 he was a Research Fellow I Junior Scientist at the Center of Neuroscience and Regenerative Medicine, in Bethesda, Maryland. From 2015 to 2017 he was a Scientist at the New York State Psychiatric Institute/ Department of Psychiatry, Columbia University, in New York City, New York. In 2017, he became the full-time faculty (Instructor) at Icahn School of Medicine at Mount Sinai in New York City, New York.

Dr. Jaiswal studies the critical role of Cu, Zn superoxide dismutase (SOD1), typical for familial ALS, in the impairment of [Ca2+]mito handling and perturbation of Ca2+ homeostasis in SOD1G93A mice and cell culture models of ALS. These finding, reported in Pharmacology and Neuroscience Journal.

Dr. Jaiswal has also studied molecular mechanisms of Traumatic Brain Injury (TBI) using 2-photon in-vivo imaging and 3-D microscopy at CNRM/NIH-DoD center. He developed a minimally invasive in-vivo 2-photon imaging method and established SCALEA2/CLARITY tissue clearing techniques for intact volumetric 3-D imaging of optically cleared transparent mouse and human brains. As a Research Scientist in the Department of Psychiatry at the Columbia University Medical Center in New York, he focused on studying adult neurogenesis in the brains of patients with major depression and other psychiatric disorders.

His lab work is conducted on mice, induced pluripotent stem cells (iPSC) and Human postmortem tissue. Dr. Jaiswal also have avid interest in science communications as well science and society. Dr. Jaiswal’s recent projects included studies related to neurodegenration in ALS Brain Injury Epigenetics and psychiatric disorders. Hyperexcitability is considered to be a hallmark of ALS, and it has been suggested that the ALS-associated hyperexcitability may stem from altered function of the neuronal glutamate receptors due to inefficient RNA editing of one of the receptor’s subunits. Immediate major focus of his work will test this hypothesis using (1) autopsied tissues obtained from brain and spinal cord of ALS patients and (2) motoneurons differentiated from human induced pluripotent stem cells (hiPSC) derived from ALS patients.

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